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Literature summary for 3.4.21.6 extracted from
- Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation (2014), Biochem. J., 462, 591-601.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | factor Xa must bind to phosphatidylserine-containing membranes to produce thrombin at a physiologically significant rate | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the enzyme is sharply regulated by a Ca2+ switch centered at 1.16 mM, below which factor Xa is active and above which factor Xa forms inactive dimers on phosphatidylserine-exposing membranes | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | Homo sapiens | - |
trhombin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Arg-Gly-L-Arg-4-nitroanilide + H2O | - |
Homo sapiens | L-Arg-Gly-L-Arg + 4-nitroaniline | - |
? | |
| prothrombin + H2O | - |
Homo sapiens | trhombin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Homo sapiens |
| FXa | - |
Homo sapiens |
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