Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Factor Va | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | activation, interaction of factor Xa with factor Va promotes prothrombin activation | thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | activation | Homo sapiens | thrombin + ? | - |
? | |
prothrombin + H2O | activation, interaction of factor Xa with factor Va promotes prothrombin activation | Homo sapiens | thrombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FXa | - |
Homo sapiens |
prothrombinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | activated protein C proteolytically inactivates factor Va through proteolytic cleavage and thereby downregulates prothrombinase. Factor Xa protects 17.3fold and prothrombin protects 5.8fold the inactivation of factor Va, while protein S increases the inactivation. Factor Xa and prothrombin together are highly protective, both with and without protein S. R506Q mutation of factor Va is only mildly prothrombotic, even though it profoundly affects the kinetics of inactivation of isolated FVa by activated protein C | down |
General Information | Comment | Organism |
---|---|---|
additional information | factor Va is the non-enzymatic cofactor of prothrombinase, which comprises, along with FVa, the enzyme factor Xa, a negatively charged phospholipid surface, and calcium ions | Homo sapiens |