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Literature summary for 3.4.21.6 extracted from

  • Kim, P.Y.; Nesheim, M.E.
    Down regulation of prothrombinase by activated protein C during prothrombin activation (2010), Thromb. Haemost., 104, 61-70.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Factor Va
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens activation, interaction of factor Xa with factor Va promotes prothrombin activation thrombin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O activation Homo sapiens thrombin + ?
-
?
prothrombin + H2O activation, interaction of factor Xa with factor Va promotes prothrombin activation Homo sapiens thrombin + ?
-
?

Synonyms

Synonyms Comment Organism
FXa
-
Homo sapiens
prothrombinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens activated protein C proteolytically inactivates factor Va through proteolytic cleavage and thereby downregulates prothrombinase. Factor Xa protects 17.3fold and prothrombin protects 5.8fold the inactivation of factor Va, while protein S increases the inactivation. Factor Xa and prothrombin together are highly protective, both with and without protein S. R506Q mutation of factor Va is only mildly prothrombotic, even though it profoundly affects the kinetics of inactivation of isolated FVa by activated protein C down

General Information

General Information Comment Organism
additional information factor Va is the non-enzymatic cofactor of prothrombinase, which comprises, along with FVa, the enzyme factor Xa, a negatively charged phospholipid surface, and calcium ions Homo sapiens