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Literature summary for 3.4.21.6 extracted from
- Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa (2011), J. Med. Chem., 54, 6125-6138.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antithrombin | heparin and antithrombin-binding sulfated pentasaccharide DEFGH, and derivatives thereof, activate antithrombin, design of two tetra-sulfated N-arylacyl tetrahydroisoquinoline variants as potential nonsaccharide activators of antithrombin, binding affinities, kinetics, and binding sites, modeling, overview. Second-order rate constants of antithrombin inhibition of factor Xa in the presence and absence of the designed activators show antithrombin activation in the range of 8-80fold at pH 6.0 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Homo sapiens |
| FXa | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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