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Literature summary for 3.4.21.6 extracted from
- Synergistic effect of a factor Xa inhibitor, TAK-442, and antiplatelet agents on whole blood coagulation and arterial thrombosis in rats (2010), Thromb. Res., 126, 124-129.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TAK-442 | potent factor Xa/prothrombinase inhibitor, acts synergistically with aspirin or clopidogrel in preventing arterial thrombosis and whole blood coagulation. TAK-442, aspirin, or clopidogrel alone have no significant effect on thrombus formation, whereas the combination of TAK-442 with aspirin and clopidogrel remarkably prolonge the time to thrombus formation without additional significant prolongation of bleeding time | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
platelet aggregation/Thrombus formation activity, overview | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Rattus norvegicus |
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