Literature summary for 3.4.21.6 extracted from

Lang, D.; Freudenberger, C.; Weinz, C.
In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans (2009), Drug Metab. Dispos., 37, 1046-1055.

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Inhibitors

Inhibitors	Comment	Organism	Structure
rivaroxaban	i.e. 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide or BAY 597939, an oral, direct factor Xa inhibitor for the prevention and treatment of thromboembolic disorders, in vitro metabolism and pathways, detailed overview	Canis lupus familiaris
rivaroxaban	i.e. 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide or BAY 597939, an oral, direct factor Xa inhibitor for the prevention and treatment of thromboembolic disorders, in vitro metabolism and pathways, detailed overview	Homo sapiens
rivaroxaban	i.e. 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide or BAY 597939, an oral, direct factor Xa inhibitor for the prevention and treatment of thromboembolic disorders, in vitro metabolism and pathways, detailed overview	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-
microsome	-	Rattus norvegicus	-	-
microsome	-	Canis lupus familiaris	-	-

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-
liver	-	Canis lupus familiaris	-

Synonyms

Synonyms	Comment	Organism
factor Xa	-	Homo sapiens
factor Xa	-	Rattus norvegicus
factor Xa	-	Canis lupus familiaris

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Release 2023.1 (January 2023)