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Literature summary for 3.4.21.6 extracted from

  • Borensztajn, K.; Peppelenbosch, M.P.; Spek, C.A.
    Factor Xa: at the crossroads between coagulation and signaling in physiology and disease (2008), Trends Mol. Med., 14, 429-440.
    View publication on PubMed
Search for more literature for 3.4.21.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme elicits a signaling response in C2C12 and NIH-3T3 fibroblast cells. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell enzyme elicits a signaling response. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts Mus musculus
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NIH-3T3 cell enzyme elicits a signaling response. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme elicits a signaling response in C2C12 and NIH-3T3 fibroblast cells. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts Mus musculus ?
-
 ?