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Literature summary for 3.4.21.6 extracted from
- Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa (2009), J. Biol. Chem., 284, 1550-1558.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R150A | modification of the complementary exosite residue that interacts with the antithrombin exosite. Mutant shows a marked attenuation of the exosite-dependent enhancement of the alpha1-proteinase inhibitor reaction | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | engineering of functional exosites in P1 Arg variant increases the association rate constant for the reactions with factors Xa and IXa, without affecting the inhibitor reactions with trypsin and thrombin. Mutation K222Y/L224E in alpha1-proteinase inhibitor increases the association rate constant 14fold | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
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Release 2023.1 (January 2023)
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