Inhibitors | Comment | Organism | Structure |
---|---|---|---|
platelet factor 4 | upon preincubation with factor Xa and heparin, platelet factor 4 at about 250 nM decreases the kcat of peptide substrate S2765 hydrolysis about fivefold and that of prothrombin activation about 25fold. In the presence of saturating fVa, inhibition of factor Xa by platelet factor is abolished, while in the presence of limiting factor Va, platelet factor 4 alters the interaction of factor Xa with factor Va. High concentrations of platelet factor 4 restore factor Xa activity toward peptide S2765 and prothrombin, indicating a dual effect of platelet factor 4 on factor Xa activities. Heparin is required to promote the formation of an fXaPF4 complex | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-Gly-Arg-4-nitroanilide + H2O | synthetic substrate S2765 | Homo sapiens | Arg-Gly-Arg + 4-nitroaniline | - |
? | |
D-Phe-Pip-Arg-4-nitroanilide + H2O | synthetic substrate S2238 | Homo sapiens | D-Phe-Pip-Arg + 4-nitroaniline | - |
? | |
prothrombin + H2O | - |
Homo sapiens | thrombin + thrombin propeptide | - |
? |