Any feedback?
Literature summary for 3.4.21.6 extracted from
- Roles of coagulation pathway and factor Xa in rat mesangioproliferative glomerulonephritis (2007), Lab. Invest., 87, 150-160.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DX-9065a | i.e. (2S)-2[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphthyl) propanoic acid hydrochloride pentahydrate, a specific factor Xa inhibitor, DX-9065a treatment significantly ameliorated proteinuria in vivo in rats with a significant reduction in the size of glomeruli, the total number of glomerular cells, and crescent formation, as well as abolishing the phosphorylation of p44/42 MAP kinase on day 8 | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | roles of coagulation pathway and factor Xa in rat mesangioproliferative glomerulonephritis, initiation of the extrinsic coagulation pathway by activating coagulation factor X to factor Xa, factor Xa promote the proliferation of mesangial cells in culture, enzyme inhibitor DX-9065a treatment significantly ameliorated proteinuria in vivo in rats with a a significant reduction in the size of glomeruli, the total number of glomerular cells, and crescent formation, as well as abolishing phosphorylation of p44/42 MAP kinase on day 8, overview | ? | - |
? | |
| prothrombin + H2O | Rattus norvegicus | - |
thrombin + propeptide of thrombin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | activation of the zymogen factor X to factor Xa by proteolytic cleavage initiates the extrinsic coagulation pathway, overview | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | roles of coagulation pathway and factor Xa in rat mesangioproliferative glomerulonephritis, initiation of the extrinsic coagulation pathway by activating coagulation factor X to factor Xa, factor Xa promote the proliferation of mesangial cells in culture, enzyme inhibitor DX-9065a treatment significantly ameliorated proteinuria in vivo in rats with a a significant reduction in the size of glomeruli, the total number of glomerular cells, and crescent formation, as well as abolishing phosphorylation of p44/42 MAP kinase on day 8, overview | Rattus norvegicus | ? | - |
? | |
| prothrombin + H2O | - |
Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
| prothrombin + H2O | factor V is a cofactor for the prothrombin activation by factor Xa | Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Factor V | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
