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Literature summary for 3.4.21.6 extracted from
- Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va (2006), J. Biol. Chem., 281, 31486-31494.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| protein S | protein S counteracted the inhibition of activated factor V by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| active site-mutated activated protein C | - |
Homo sapiens | |
| dansyl-Glu-Gly-Arg | - |
Homo sapiens |  |
| protein S | protein S counteracted the inhibition of activated factor V by FXa of the Arg506 cleavage, leading to 50% reduced activity, whereas protein S and FXa yielded a 3fold additive stimulatory effect of the cleavage at Arg306, annihilation of the FXa protection of the Arg506 cleavage by protein S is due to an enhanced rate of Arg506 cleavage of FVa not bound to FXa, resulting in depletion of free FVa and dissociation of FXa-FVa complexes | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | factor Xa inhibits the inhibition of the procoagulant function of activated factor V by activated protein C through proteolytic cleavages at Arg506, with a half-maximum inhibition of 2 nM, while the cleavage at Arg306, and Arg679 is not protected, protein S counteracted the inhibition by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306, activity with recombinant FVa Q306/Q679 and FVa Q506/Q679 variants, interaction analysis with 1.5-dansyl-Glu-Gly-Arg-inhibited factor Xa, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | factor Xa inhibits the inhibition of the procoagulant function of activated factor V by activated protein C through proteolytic cleavages at Arg506, with a half-maximum inhibition of 2 nM, while the cleavage at Arg306, and Arg679 is not protected, protein S counteracted the inhibition by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306, activity with recombinant FVa Q306/Q679 and FVa Q506/Q679 variants, interaction analysis with 1.5-dansyl-Glu-Gly-Arg-inhibited factor Xa, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Homo sapiens |
| FXa | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
FVa inhibition assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
FVa inhibition assay at | Homo sapiens |
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