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Literature summary for 3.4.21.6 extracted from

  • Borensztajn, K.S.; Bijlsma, M.F.; Groot, A.P.; Brueggemann, L.W.; Versteeg, H.H.; Reitsma, P.H.; Peppelenbosch, M.P.; Spek, C.A.
    Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation (2007), Exp. Cell Res., 313, 2622-2633.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by hirudin Homo sapiens
tick anticoagulant peptide TAP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens coagulation factor Xa is a serine protease that plays a crucial role during blood coagulation by converting prothrombin into thrombin, it drives tumor cells of epithelial, but not endothelial, origin into apoptosis through BH3-only protein Bim up-regulation, and enhances fibroblast survival, overview, signaling through protease-activated receptor 1, PAR-1, with rapid and transient desensitization of PAR-1 signaling, signaling pathway, overview ?
-
 ?
prothrombin + H2O Homo sapiens proteolytic activation thrombin + propeptide of thrombin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information coagulation factor Xa is a serine protease that plays a crucial role during blood coagulation by converting prothrombin into thrombin, it drives tumor cells of epithelial, but not endothelial, origin into apoptosis through BH3-only protein Bim up-regulation, and enhances fibroblast survival, overview, signaling through protease-activated receptor 1, PAR-1, with rapid and transient desensitization of PAR-1 signaling, signaling pathway, overview Homo sapiens ?
-
 ?
prothrombin + H2O
-
 Homo sapiens thrombin + propeptide of thrombin
-
 ?
prothrombin + H2O proteolytic activation Homo sapiens thrombin + propeptide of thrombin
-
 ?

Synonyms

Synonyms Comment Organism
FXa
-
 Homo sapiens