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Literature summary for 3.4.21.6 extracted from

  • Faure, G.; Gowda, V.T.; Maroun, R.C.
    Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics (2007), BMC Struct. Biol., 7, 82.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
Viperidae snake venom group IIA secreted phospholipases A2 i.e. SVPLA2, different isoforms, overview, FXa strong-binding SVPLA2s CBc, MtxII, CbII and CBa2 inactivate factor Xa by direct binding and by interacting with FXa by the non-catalytic phospholipid-independent mechanism, identification of the potential FXa binding site, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information FXa binding kinetic parameters and effect on prothrombinase activity of Viperidae SVPLA2 isoforms, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens different anticoagulant mechanisms, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00742
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin residues His57, Asp102, and Ser195 form the catalytic triad at the active site cleft between the two subdomains Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information different anticoagulant mechanisms, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More FXa circulates as light and the heavy chains connected by a single disulfide linkage in plasma Homo sapiens

Synonyms

Synonyms Comment Organism
FXa
-
 Homo sapiens