Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Homo sapiens | |
additional information | formation of the prothrombinase enzyme complex increases the factor Xa activity by 300000fold, the complex includes phospholipids, Ca2+, factor Xa and factor Va | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5-dansyl-Glu-Gly-Arg chloromethyl ketone | slow binding inhibitor | Homo sapiens | |
4-hydroxy-3-[2-oxo-3-(S)-(5-pyridin-3-yl-thiophene-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine | i.e. RPR130737, highly specific inhibitor of factor Xa realtive to other serine proteases, reversible, fast binding, competitive active-site directed inhibitor | Homo sapiens | |
DX-9065a | fast-binding inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Arg-Gly-Arg-4-nitroanilide + H2O | chromogenic synthetic substrate S2765 | Homo sapiens | L-Arg-Gly-Arg + 4-nitroaniline | - |
? | |
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | formation of the prothrombinase enzyme complex increases the factor Xa activity by 300000fold, the complex includes phospholipids, Ca2+, factor Xa and factor Va | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
room temperature, assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000024 | - |
4-hydroxy-3-[2-oxo-3-(S)-(5-pyridin-3-yl-thiophene-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine | pH 7.5, 22°C | Homo sapiens |