Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | i.e. FXV673, highly specific fo factor Xa compared to other serine protesases, increases the coagulation time, inhibition kinetics of the enzyme complex bound factor Xa, inhibition of thrombus formation in vivo in the acute arterial and venous electrolytic injury canine model, no effect on platelet aggregation | Canis lupus familiaris | |
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | i.e. FXV673, highly specific fo factor Xa compared to other serine proteases, increases the coagulation time, inhibition kinetics of the enzyme complex bound factor Xa, no effect on platelet aggregation | Homo sapiens | |
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | i.e. FXV673, highly specific fo factor Xa compared to other serine protesases, increases the coagulation time, inhibition kinetics of the enzyme complex bound factor Xa, no effect on platelet aggregation | Oryctolagus cuniculus | |
EDTA | - |
Canis lupus familiaris | |
EDTA | - |
Homo sapiens | |
EDTA | - |
Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Oryctolagus cuniculus | - |
- |
extracellular | - |
Canis lupus familiaris | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
mongrel dogs of either sex | - |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens | |
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Oryctolagus cuniculus | |
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
commercial preparation | - |
Oryctolagus cuniculus | - |
commercial preparation | - |
Canis lupus familiaris | - |
plasma | - |
Homo sapiens | - |
plasma | - |
Oryctolagus cuniculus | - |
plasma | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
prothrombin + H2O | - |
Oryctolagus cuniculus | thrombin + ? | - |
? | |
prothrombin + H2O | - |
Canis lupus familiaris | thrombin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme is part of the prothrombinase enzyme complex including also factor Va, phospholipids and Ca2+ | Homo sapiens |
More | enzyme is part of the prothrombinase enzyme complex including also factor Va, phospholipids and Ca2+ | Oryctolagus cuniculus |
More | enzyme is part of the prothrombinase enzyme complex including also factor Va, phospholipids and Ca2+ | Canis lupus familiaris |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
factor Xa | - |
Oryctolagus cuniculus |
factor Xa | - |
Canis lupus familiaris |
FXa | - |
Homo sapiens |
FXa | - |
Oryctolagus cuniculus |
FXa | - |
Canis lupus familiaris |
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Oryctolagus cuniculus |
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Canis lupus familiaris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Oryctolagus cuniculus |
7.5 | - |
assay at | Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000027 | - |
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | pH 7.5, 37°C | Oryctolagus cuniculus | |
0.00000052 | - |
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | pH 7.5, 37°C | Homo sapiens | |
0.00000141 | - |
2-(R)-(3-carbamimidoylbenzyl)-3-(R)-[4-(1-oxypyridin-4-yl)benzoylamino]-butyric acid methyl ester | pH 7.5, 37°C | Canis lupus familiaris |