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Literature summary for 3.4.21.6 extracted from
- Recent advances in the discovery and development of direct coagulation factor Xa inhibitors (2003), Curr. Pharm. Des., 9, 2337-2347.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is a target for discovery, design of direct inhibitors and development of antithrombotic agents, overview | Homo sapiens |
| pharmacology | enzyme is a target for discovery, design of direct inhibitors and development of antithrombotic agents, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | Homo sapiens | enzyme is involved in thrombotic complications of artherosclerosis and following diseases, overview | thrombin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
| prothrombin + H2O | enzyme is involved in thrombotic complications of artherosclerosis and following diseases, overview | Homo sapiens | thrombin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Homo sapiens |
| More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
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