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Literature summary for 3.4.21.6 extracted from

  • Oliva, M.L.V.; Andrade, S.A.; Juliano, M.A.; Sallai, R.C.; Torquato, R.J.; Sampaio, M.U.; Pott, V.J.; Sampaio, C.A.M.
    Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor from Bauhinia ungulata seeds (2003), Curr. Med. Chem., 10, 1085-1093.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
Bauhinia ungulata factor Xa inhibitor i.e. BuXI, specific Kunitz-type inhibitor of factor Xa, methionine residues at the active site of the inhibitor are involved in the inhibition mechanism, oxidized protein does no longer inhibit factor Xa Homo sapiens
additional information no inhibition by the Bauhinia variegata trypsin inhibitor BvTI Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-VMIAALPRTMFIQ-ED-dinitrophenyl + H2O
-
 Homo sapiens ?
-
 ?
additional information substrate specificity, no activity with a substrate containing the active site sequence of the Bauhinia variegata trypsin inhibitor BvTI Homo sapiens ?
-
 ?
N-alpha-benzyloxycarbonyl-Ile-Glu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-benzyloxycarbonyl-Ile-Glu-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000014
-
 BuXI
-
 Homo sapiens