Application | Comment | Organism |
---|---|---|
pharmacology | enzyme is a target for inhibitor design as anti-thrombotic agents | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl 3-[3-[amino(imino)methyl]phenyl]-5-[4-[amino(imino)methyl]phenyl]pentanoate | - |
Bos taurus | |
additional information | inhibition mechanism, inhibitor binding | Bos taurus | |
N-1-adamantylaminocarbonyl-D,L-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-(R)-3-amidinophenylalanine-(2-phenyl)-1-ethylamide | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine benzylamide | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-(R)-L-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine piperidine | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-D,L-4-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-1-adamantyloxycarbonyl-D,L-4-guanidinophenylalanine methyl ester | - |
Bos taurus | |
N-9-fluorenemethyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
N-benzyloxycarbonyl-D,L-3-amidinophenylalanine piperidine | - |
Bos taurus | |
N-tert-butyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | - |
Bos taurus | |
Nalpha-4'-amidinobenzensulfonyl-glycyl-D,L-4-amimidinophenylalanine ethyl ester | - |
Bos taurus | |
Nalpha-tosylglycyl-D,L-3-amidinophenylalanine alkyl ester | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Bos taurus | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Bos taurus | thrombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000034 | - |
methyl 3-[3-[amino(imino)methyl]phenyl]-5-[4-[amino(imino)methyl]phenyl]pentanoate | pH 8.0, 25°C | Bos taurus | |
0.000074 | - |
N-1-adamantyloxycarbonyl-(R)-3-amidinophenylalanine-(2-phenyl)-1-ethylamide | pH 8.0, 25°C | Bos taurus | |
0.00022 | - |
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine benzylamide | pH 8.0, 25°C | Bos taurus | |
0.00039 | - |
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.0005 | - |
Nalpha-4'-amidinobenzensulfonyl-glycyl-D,L-4-amimidinophenylalanine ethyl ester | pH 8.0, 25°C | Bos taurus | |
0.00062 | - |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.00084 | - |
Nalpha-tosylglycyl-D,L-3-amidinophenylalanine alkyl ester | pH 8.0, 25°C | Bos taurus | |
0.0009 | - |
N-1-adamantylaminocarbonyl-D,L-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.0014 | - |
N-1-adamantyloxycarbonyl-D,L-4-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.0017 | - |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine piperidine | pH 8.0, 25°C | Bos taurus | |
0.0021 | - |
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine | pH 8.0, 25°C | Bos taurus | |
0.0034 | - |
N-9-fluorenemethyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.0046 | - |
N-1-adamantyloxycarbonyl-(R)-L-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.016 | - |
N-tert-butyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus | |
0.033 | - |
N-benzyloxycarbonyl-D,L-3-amidinophenylalanine piperidine | pH 8.0, 25°C | Bos taurus | |
1 | - |
N-1-adamantyloxycarbonyl-D,L-4-guanidinophenylalanine methyl ester | pH 8.0, 25°C | Bos taurus |