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Literature summary for 3.4.21.6 extracted from

  • Sperl, S.; Bergner, A.; Sturzebecher, J.; Magdolen, V.; Bode, W.; Moroder, L.
    Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies (2000), Biol. Chem., 381, 321-329.
    View publication on PubMed

Application

Application Comment Organism
pharmacology enzyme is a target for inhibitor design as anti-thrombotic agents Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
methyl 3-[3-[amino(imino)methyl]phenyl]-5-[4-[amino(imino)methyl]phenyl]pentanoate
-
Bos taurus
additional information inhibition mechanism, inhibitor binding Bos taurus
N-1-adamantylaminocarbonyl-D,L-3-amidinophenylalanine methyl ester
-
Bos taurus
N-1-adamantyloxycarbonyl-(R)-3-amidinophenylalanine-(2-phenyl)-1-ethylamide
-
Bos taurus
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine benzylamide
-
Bos taurus
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine methyl ester
-
Bos taurus
N-1-adamantyloxycarbonyl-(R)-L-3-amidinophenylalanine methyl ester
-
Bos taurus
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine
-
Bos taurus
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester
-
Bos taurus
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine piperidine
-
Bos taurus
N-1-adamantyloxycarbonyl-D,L-4-amidinophenylalanine methyl ester
-
Bos taurus
N-1-adamantyloxycarbonyl-D,L-4-guanidinophenylalanine methyl ester
-
Bos taurus
N-9-fluorenemethyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester
-
Bos taurus
N-benzyloxycarbonyl-D,L-3-amidinophenylalanine piperidine
-
Bos taurus
N-tert-butyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester
-
Bos taurus
Nalpha-4'-amidinobenzensulfonyl-glycyl-D,L-4-amimidinophenylalanine ethyl ester
-
Bos taurus
Nalpha-tosylglycyl-D,L-3-amidinophenylalanine alkyl ester
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Bos taurus
-
thrombin + ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
Bos taurus thrombin + ?
-
?

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000034
-
methyl 3-[3-[amino(imino)methyl]phenyl]-5-[4-[amino(imino)methyl]phenyl]pentanoate pH 8.0, 25°C Bos taurus
0.000074
-
N-1-adamantyloxycarbonyl-(R)-3-amidinophenylalanine-(2-phenyl)-1-ethylamide pH 8.0, 25°C Bos taurus
0.00022
-
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine benzylamide pH 8.0, 25°C Bos taurus
0.00039
-
N-1-adamantyloxycarbonyl-(R)-D-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.0005
-
Nalpha-4'-amidinobenzensulfonyl-glycyl-D,L-4-amimidinophenylalanine ethyl ester pH 8.0, 25°C Bos taurus
0.00062
-
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.00084
-
Nalpha-tosylglycyl-D,L-3-amidinophenylalanine alkyl ester pH 8.0, 25°C Bos taurus
0.0009
-
N-1-adamantylaminocarbonyl-D,L-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.0014
-
N-1-adamantyloxycarbonyl-D,L-4-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.0017
-
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine piperidine pH 8.0, 25°C Bos taurus
0.0021
-
N-1-adamantyloxycarbonyl-D,L-3-amidinophenylalanine pH 8.0, 25°C Bos taurus
0.0034
-
N-9-fluorenemethyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.0046
-
N-1-adamantyloxycarbonyl-(R)-L-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.016
-
N-tert-butyloxycarbonyl-D,L-3-amidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus
0.033
-
N-benzyloxycarbonyl-D,L-3-amidinophenylalanine piperidine pH 8.0, 25°C Bos taurus
1
-
N-1-adamantyloxycarbonyl-D,L-4-guanidinophenylalanine methyl ester pH 8.0, 25°C Bos taurus