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Literature summary for 3.4.21.59 extracted from

  • Janke, D.; Sommerhoff, C.P.; Schaschke, N.
    The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors (2011), Bioorg. Med. Chem., 19, 7236-7243.
    View publication on PubMed
Search for more literature for 3.4.21.59

Inhibitors

Inhibitors Comment Organism Structure
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
 Homo sapiens
c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
 Homo sapiens
c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-]
-
 Homo sapiens
c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-]
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
beta-tryptase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000007
-
 c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-] pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000025
-
 c[-Pro-beta3hPhe(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHCO-(CH2)5-NH2)-CO-] pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.04
-
 c[-Pro-beta3hArg(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-] pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.38
-
 c[-Pro-beta3Lys(3-H2N-CH2)-D-allo-Ile-vTyr-NH-CH2-CH(NHAc)-CO-] pH not specified in the publication, temperature not specified in the publication Homo sapiens