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Literature summary for 3.4.21.59 extracted from

  • Yamagishi, H.; Mochizuki, Y.; Hamakubo, T.; Obata, K.; Ugajin, T.; Sato, S.; Kawano, Y.; Minegishi, Y.; Karasuyama, H.
    Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner (2011), Biochem. Biophys. Res. Commun., 415, 709-713.
    View publication on PubMed
Search for more literature for 3.4.21.59

Cloned(Commentary)

Cloned (Comment) Organism
version with Flag peptide and enterokinase-cleavage site expressed in Sf9 insect cells Mus musculus

Protein Variants

Protein Variants Comment Organism
S200A part of catalytic triad, inactive Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus

Purification (Commentary)

Purification (Comment) Organism
immunoprecipitation (anti-FLAG M2 agarose), enterokinase cleavage Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
basophil
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000000055
-
 substrate tosyl-Gly-Pro-Lys-4-nitroanilide, pH not specified in the publication, temperature not specified in the publication Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
-
 Mus musculus tosyl-Gly-Pro-Lys + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
mast cell protease 11 member of tryptase family Mus musculus

General Information

General Information Comment Organism
physiological function can induce microvascular leakage via prostaglandins in a mast cell-independent manner and may contribute to the development of basophil-mediated inflammatory responses Mus musculus