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Literature summary for 3.4.21.59 extracted from
- Reversible and noncompetitive inhibition of Œ?-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library (2010), Angew. Chem. Int. Ed. Engl., 49, 4113-4116.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| lung beta-tryptase, commercial preparation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2 | noncompetitive | Homo sapiens |  |
| (Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2 | noncompetitive | Homo sapiens | |
| 4-aminobenzamidine | - |
Homo sapiens | |
| Arg-Trp-Lys-Gly-NH2 | noncompetitive | Homo sapiens | |
| Lys-Lys-Phe-Gly-NH2 | noncompetitive | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| commercial preparation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Tos-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Tos-Gly-Pro-Arg + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-tryptase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00017 | - |
(Arg-Trp-Lys-Gly)4(Lys)2Lys-NH2 | 22°C, pH not specified in the publication | Homo sapiens | |
| 0.000323 | - |
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2 | 22°C, pH not specified in the publication | Homo sapiens | |
| 0.00063 | - |
(Lys-Lys-Phe-Gly)4(Lys)2Lys-NH2 | 22°C, pH not specified in the publication | Homo sapiens | |
| 0.05697 | - |
4-aminobenzamidine | 22°C, pH not specified in the publication | Homo sapiens | |
| 0.3058 | - |
Arg-Trp-Lys-Gly-NH2 | 22°C, pH not specified in the publication | Homo sapiens | |
| 0.4717 | - |
Lys-Lys-Phe-Gly-NH2 | 22°C, pH not specified in the publication | Homo sapiens | |
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Release 2023.1 (January 2023)
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