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Literature summary for 3.4.21.59 extracted from
- Mast cell tryptase promotes breast cancer migration and invasion (2010), Oncol. Rep., 23, 615-619.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-matrix metalloproteinase-2 + H2O | Homo sapiens | - |
matrix metalloproteinase-2 + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | significantly more tryptase in peritumoral tissue than in normal breast tissue | Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-matrix metalloproteinase-2 + H2O | - |
Homo sapiens | matrix metalloproteinase-2 + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mast cell tryptase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | increased tryptase is associated with higher tumor grade and more lymph node metastasis in breast cancer tissue | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tryptase promotes the invasion and migration of breast cancer cells along with activation of matrix metalloproteinase-2. Tryptase does not affect the proliferation of the cells. Tryptase promotes breast cancer migration and invasion | Homo sapiens |
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Release 2023.1 (January 2023)
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