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Literature summary for 3.4.21.59 extracted from
- Active monomers of human beta-tryptase have expanded substrate specificities (2007), Int. Immunopharmacol., 7, 1900-1908.
General Stability
| General Stability | Organism |
|---|---|
| heparin-proteoglycan stabilizes the active enzyme monomers | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antithrombin III | - |
Homo sapiens | |
| BPTI | - |
Homo sapiens | |
| SBTII | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secreted from activated mast cells | Homo sapiens | - |
- |
| secretory granule | - |
Homo sapiens | 30141 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
enzyme-antithrombin III complex, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component 3 + H2O | Homo sapiens | digestion | ? | - |
? | |
| Fibrinogen + H2O | Homo sapiens | digestion | ? | - |
? | |
| Fibronectin + H2O | Homo sapiens | digestion | ? | - |
? | |
| additional information | Homo sapiens | beta-tryptase is involved in the pathogenesis of airway inflammation, the enzyme accounts for more than 25% or total protein in human mast cells, activated cells release the enzyme along with histamine and heparin proteoflycans, overview | ? | - |
? | |
| pro-matrix metalloprotease-3 + H2O | Homo sapiens | digestion | ? | - |
? | |
| Pro-urokinase + H2O | Homo sapiens | digestion | ? | - |
? | |
| protease-activated receptor-2 + H2O | Homo sapiens | digestion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
genes TPSAB 1 and TPSB2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme by gel filtration | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| reconstitution of active tetramer from inactive monomers, overview | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | synthesis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component 3 + H2O | digestion | Homo sapiens | ? | - |
? | |
| Fibrinogen + H2O | digestion | Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | digestion | Homo sapiens | ? | - |
? | |
| additional information | beta-tryptase is involved in the pathogenesis of airway inflammation, the enzyme accounts for more than 25% or total protein in human mast cells, activated cells release the enzyme along with histamine and heparin proteoflycans, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a serine protease that is a major and selective component of the secretory granules of all human mast cells, active monomers of human beta-tryptase have expanded substrate specificities, overview | Homo sapiens | ? | - |
? | |
| pro-matrix metalloprotease-3 + H2O | digestion | Homo sapiens | ? | - |
? | |
| Pro-urokinase + H2O | digestion | Homo sapiens | ? | - |
? | |
| protease-activated receptor-2 + H2O | digestion | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | a homotetramer with the active sites facing into the central cavity of the four monomers, the monomers are active, when stabilized by heparin-proteoglycan, and have expanded substrate specificities, overview | Homo sapiens |
| tetramer | a homotetramer with the active sites facing into the central cavity of the four monomers, the monomers are active, when stabilized by heparin-proteoglycan, and have expanded substrate specificities, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-tryptase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
assay at | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
inactivation of active monomers at neutral pH without stabilization by heparin-proteoglycans | Homo sapiens |
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