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Literature summary for 3.4.21.59 extracted from
- Biology of mast cell tryptase. An inflammatory mediator (2006), FEBS J., 273, 1871-1895.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression pattern and sequence comparisons of isozymes, overview | Mus musculus |
| expression pattern and sequence comparisons of isozymes, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | alpha-tryptase is present at low levels in the circulation, even in the absence of mast cell degranulation | Homo sapiens | - |
- |
| extracellular | extracellular matrix that surrounds the degranulated mast cell, MCP-6 | Mus musculus | - |
- |
| secretory granule | - |
Mus musculus | 30141 | - |
| secretory granule | - |
Homo sapiens | 30141 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is an inflammation mediator | ? | - |
? |  |
| additional information | Mus musculus | the enzyme is an inflammation mediator, mMCP-6 is a major storage component of connective tissue-type mast cells, and is not normally released into the environment | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57BL/6 mice, no TMT activity in but not BALB/c or 129/Sv mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ear | connective tissues of adult mice, MCP-7 | Mus musculus | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| HMC-1 cell | isozyme gammaI-tryptase and gammaII-tryptase | Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| mast cell | airway mast cells and mast cell-like cell line, HMC-1, delta-tryptase is primarily expressed by mast cells, in tissues such as colon, lung and heart as well as in HMC-1 cells | Homo sapiens | - |
| mast cell | mMCP-6 is exclusively expressed in connective tissuetype mast cells, mMCP-7 occurs in early stage cultures of bone marrow-derived mast cells, MCP-11 expression is highest at early stages of mast cell development | Mus musculus | - |
| additional information | mMCP-6, mMCP-7 can be detected in plasma as early as 20 min after mast cell degranulation | Mus musculus | - |
| plasma | - |
Mus musculus | - |
| skin | connective tissues of adult mice, MCP-7 | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is an inflammation mediator | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is an inflammation mediator, mMCP-6 is a major storage component of connective tissue-type mast cells, and is not normally released into the environment | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | alpha- and beta-tryptase, active form | Mus musculus |
| tetramer | alpha- and beta-tryptase, active form | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-tryptase | - |
Mus musculus |
| alpha-tryptase | - |
Homo sapiens |
| beta-tryptase | - |
Mus musculus |
| beta-tryptase | - |
Homo sapiens |
| delta-tryptase | - |
Mus musculus |
| delta-tryptase | - |
Homo sapiens |
| gamma-tryptase | - |
Mus musculus |
| gamma-tryptase | - |
Homo sapiens |
| Mast cell tryptase | - |
Mus musculus |
| Mast cell tryptase | - |
Homo sapiens |
| MCP-11 | - |
Mus musculus |
| MCP-6 | - |
Mus musculus |
| MCP-7 | - |
Mus musculus |
| Prss31 | - |
Mus musculus |
| TMT | - |
Mus musculus |
| transmembrane tryptase | - |
Mus musculus |
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