Literature summary for 3.4.21.59 extracted from

Miyazaki, Y.; Kato, Y.; Manabe, T.; Shimada, H.; Mizuno, M.; Egusa, T.; Ohkouchi, M.; Shiromizu, I.; Matsusue, T.; Yamamoto, I.
Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors (2006), Bioorg. Med. Chem. Lett., 16, 2986-2990.

Search for more literature for 3.4.21.59

Inhibitors

Inhibitors	Comment	Organism	Structure
M58539	i.e. N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(1-chloronaphthalen-2-yl)sulfanyl]ethane-1,2-diamine, a highly selective inhibitor	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
beta-tryptase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000005	-	M58539	-	Homo sapiens
0.000073	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(naphthalen-2-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
0.00013	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-2-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
0.00019	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1,2,3,4-tetrahydroisoquinolin-7-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
0.0002	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(2,3-dihydro-1H-inden-5-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
0.00021	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(1-benzothiophen-5-ylsulfanyl)ethane-1,2-diamine	-	Homo sapiens
0.00027	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-[(2-methyl-1,3-benzothiazol-6-yl)sulfanyl]ethane-1,2-diamine	-	Homo sapiens
0.00076	-	N-[3-[4-(aminomethyl)phenyl]propyl]-N'-(phenylsulfanyl)ethane-1,2-diamine	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)