Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FUT175 | a selective tryptase inhibitor | Homo sapiens | |
leupeptin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
TGFbeta + H2O | Homo sapiens | tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview | activated TGFbeta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
airway smooth muscle | - |
Homo sapiens | - |
commercial preparation | purified from lung | Homo sapiens | - |
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
TGFbeta + H2O | activation | Homo sapiens | activated TGFbeta + ? | - |
? | |
TGFbeta + H2O | tryptase activates TGFbeta, a key remodelling factor in asthma, in human airway smooth muscle cells via direct proteolysis in a PAR2-independent manner, TGFbeta is produced as a latent complex and the main limiting step in TGFb bioavailability is its activation, overview | Homo sapiens | activated TGFbeta + ? | - |
? |