Application | Comment | Organism |
---|---|---|
drug development | beta-tryptases are the major focus of drug development for therapeutic inhibition | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genetic localization | Mus musculus |
genetic localization | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MOL 6131 | developed against mast cell beta-tryptase and studied in ovalbumin-induced allergic airway inflammation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchored, gamma-tryptase, i.e. transmembrane tryptase | Mus musculus | 16020 | - |
membrane | anchored, gamma-tryptase, i.e. transmembrane tryptase | Homo sapiens | 16020 | - |
soluble | alpha-, beta-, and delta-tryptase | Mus musculus | - |
- |
soluble | alpha-, beta-, and delta-tryptase | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in allergic inflammation, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme is involved in allergic inflammation, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several enzyme forms | - |
Mus musculus | - |
C57BL/6 mice, several enzyme forms | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
basophil | beta-tryptase | Mus musculus | - |
basophil | beta-tryptase | Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
mast cell | - |
Mus musculus | - |
mast cell | - |
Homo sapiens | - |
respiratory system | - |
Mus musculus | - |
respiratory system | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in allergic inflammation, mechanism, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in allergic inflammation, mechanism, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | structure of enzyme forms, overview | Mus musculus |
tetramer | structure of enzyme forms, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
alpha-tryptase | - |
Mus musculus |
alpha-tryptase | - |
Homo sapiens |
beta-tryptase | - |
Mus musculus |
beta-tryptase | - |
Homo sapiens |
delta-tryptase | - |
Mus musculus |
delta-tryptase | - |
Homo sapiens |
gamma-tryptase | - |
Mus musculus |
gamma-tryptase | - |
Homo sapiens |
Mast cell tryptase | - |
Mus musculus |
Mast cell tryptase | - |
Homo sapiens |
transmembrane tryptase | - |
Mus musculus |
transmembrane tryptase | - |
Homo sapiens |