Literature summary for 3.4.21.59 extracted from

Costanzo, M.J.; Yabut, S.C.; Almond, H.R., Jr.; Andrade-Gordon, P.; Corcoran, T.W.; De Garavilla, L.; Kauffman, J.A.; Abraham, W.M.; Recacha, R.; Chattopadhyay, D.; Maryanoff, B.E.
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone (2003), J. Med. Chem., 46, 3865-3876.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2,5-dihydro-1H-pyrrole-2-carboxamide	-	Homo sapiens
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2-azetidinearboxamide	-	Homo sapiens
(2S)-1-acetyl-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-2-pyrrolidinecarboxamide	-	Homo sapiens
(2S)-2-acetylamino-N-[4-[(aminoiminomethyl)amino]-1-(2-benzothiazolylcarbonyl)butyl]-4-methylpentanamide	-	Homo sapiens
CRA-2059	-	Homo sapiens
RWJ-56423	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
human mast cell tryptase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000062	-	CRA-2059	pH 8.0, 25°C, tryptase-beta	Homo sapiens
0.000001	-	RWJ-56423	pH 7.4, 37°C	Homo sapiens

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Release 2023.1 (January 2023)