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Literature summary for 3.4.21.55 extracted from

  • Kalogeropoulos, K.; Treschow, A.F.; Auf dem Keller, U.; Escalante, T.; Rucavado, A.; Gutierrez, J.M.; Laustsen, A.H.; Workman, C.T.
    Protease activity profiling of snake venoms using high-throughput peptide screening (2019), Toxins, 11, 170 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.55

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Bitis gabonica
-
-

Organism

Organism UniProt Comment Textmining
Bitis gabonica
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Bitis gabonica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bovine prothrombin + H2O
-
 Bitis gabonica ?
-
 ?
coagulation factor VIII + H2O moderate activity Bitis gabonica ?
-
 ?
collagen alpha-2(I) chain + H2O moderate activity Bitis gabonica ?
-
 ?
FSARGHRP + H2O a peptide derived from human fibrinogen beta-chain Bitis gabonica ?
-
 ?
human fibrinogen beta-chain + H2O low activity Bitis gabonica ?
-
 ?
human prothrombin + H2O moderate activity Bitis gabonica ?
-
 ?
integrin alpha-6 + H2O higher activity Bitis gabonica ?
-
 ?
kininogen-1 + H2O higher activity Bitis gabonica ?
-
 ?
additional information substrate specificity, use of an donor-acceptor detection method for the investigation of proteinase activity of selected crude venoms in a high-throughput setup, enzyme activity comparisons of different species, overview. Analysis and heatmaps of coagulation factors, inflammation-associated proteins, and collagen and integrin-derived peptides during incubation with venom. All of the substrates against which activity is observed in the inhibition experiments contain arginine residues in their sequences Bitis gabonica ?
-
 ?

Synonyms

Synonyms Comment Organism
venom serine proteinase
-
 Bitis gabonica

General Information

General Information Comment Organism
evolution the enzyme belongs to the family of snake venom serine proteinases (SVSPs), phylogenetic analysis of the snakes Bitis gabonica