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Literature summary for 3.4.21.54 extracted from

  • Poe, M.; Wu, J.K.; Florance, J.R.; Rodkey, J.A.; Bennett, C.D.; Hoogsteen, K.
    Purification and properties of renin and gamma-renin from the mouse submaxillary gland (1983), J. Biol. Chem., 258, 2209-2216.
    View publication on PubMed
Search for more literature for 3.4.21.54

Inhibitors

Inhibitors Comment Organism Structure
benzamidine inhibitis cleavage of synthetic tetradecapeptide renin substrate, competitive inhibitor of benzoyl-arginine 4-nitroanilide hydrolysis Mus musculus
diisopropyl fluorophosphate inhibits cleavage of synthetic tetradecapeptide renin substrate, irreversible inhibition of benzoyl-arginine 4-nitroanilide Mus musculus
pepstatin inhibits cleavage of synthetic tetradecapeptide renin substrate, competitive inhibitor of benzoyl-arginine 4-nitroanilide hydrolysis Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.038
-
 benzoyl-Arg 4-nitroanilide
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7200
-
 x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol Mus musculus
26000
-
 x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus it is proposed that gamma-renin in mouse saliva cleaves peptides which are homologous to angiotensinogen and have potent vasoactivity and action in the central nervous system ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male
-

Purification (Commentary)

Purification (Comment) Organism
male Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
submandibular gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Arg 4-nitroanilide + H2O
-
 Mus musculus benzoyl-Arg + 4-nitroaniline
-
 ?
additional information no production of angiotensin I from hog angiotensinogen Mus musculus ?
-
 ?
additional information it is proposed that gamma-renin in mouse saliva cleaves peptides which are homologous to angiotensinogen and have potent vasoactivity and action in the central nervous system Mus musculus ?
-
 ?
Synthetic tetradecapeptide renin substrate + H2O
-
 Mus musculus Angiotensin I
-
 ?

Subunits

Subunits Comment Organism
? x * 26000, mouse, SDS-PAGE without reducing agent, x * 7200 + x * 4400, mouse, SDS-PAGE after reduction with 2-mercaptoethanol Mus musculus