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Literature summary for 3.4.21.53 extracted from

  • Gimenez, M.; Cerletti, M.; De Castro, R.
    Archaeal membrane-associated proteases Insights on Haloferax volcanii and other haloarchaea (2015), Front. Microbiol., 6, 39 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.53

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure determination at 2.0 A resolution Thermococcus onnurineus
crystal structure determination of LonB proteolytic domain Archaeoglobus fulgidus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane has two transmembrane domains Natrialba magadii
-
-
cell membrane has two transmembrane domains Haloferax volcanii
-
-
membrane has one transmembrane domains Archaeoglobus fulgidus 16020
-
membrane has two transmembrane domains Thermococcus kodakarensis 16020
-
membrane has two transmembrane domains Thermoplasma acidophilum 16020
-
membrane has two transmembrane domains Thermococcus onnurineus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Thermococcus kodakarensis
Mg2+ required Archaeoglobus fulgidus
Mg2+ required Thermoplasma acidophilum
Mg2+ required Natrialba magadii
Mg2+ required Thermococcus onnurineus
Mg2+ required Haloferax volcanii

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus O29883
-
-
Archaeoglobus fulgidus ATCC 49558 O29883
-
-
Archaeoglobus fulgidus JCM 9628 O29883
-
-
Archaeoglobus fulgidus NBRC 100126 O29883
-
-
Archaeoglobus fulgidus VC-16 O29883
-
-
Haloferax volcanii D4GTT9
-
-
Haloferax volcanii ATCC 29605 D4GTT9
-
-
Haloferax volcanii DS2 D4GTT9
-
-
Haloferax volcanii DSM 3757 D4GTT9
-
-
Haloferax volcanii JCM 8879 D4GTT9
-
-
Haloferax volcanii NBRC 14742 D4GTT9
-
-
Haloferax volcanii NCIMB 2012 D4GTT9
-
-
Haloferax volcanii VKM B-1768 D4GTT9
-
-
Natrialba magadii C5MK48
-
-
Natrialba magadii ATCC 43099 C5MK48
-
-
Natrialba magadii CIP 104546 C5MK48
-
-
Natrialba magadii DSM 3394 C5MK48
-
-
Natrialba magadii JCM 8861 C5MK48
-
-
Natrialba magadii MS3 C5MK48
-
-
Natrialba magadii NBRC 102185 C5MK48
-
-
Natrialba magadii NCIMB 2190 C5MK48
-
-
Thermococcus kodakarensis Q8NKS6
-
-
Thermococcus onnurineus B6YU74
-
-
Thermoplasma acidophilum Q9HJ89
-
-
Thermoplasma acidophilum AMRC-C165 Q9HJ89
-
-
Thermoplasma acidophilum ATCC 25905 Q9HJ89
-
-
Thermoplasma acidophilum JCM 9062 Q9HJ89
-
-
Thermoplasma acidophilum NBRC 15155 Q9HJ89
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii ?
-
 ?
additional information LonB protease shows ATPase and protease activities Archaeoglobus fulgidus ?
-
 ?
additional information LonB protease shows ATPase and protease activities Thermococcus onnurineus ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii ?
-
 ?
additional information LonB protease shows ATPase and protease activities. Membrane-bound ATP-dependent Lon protease from Thermococcus kodakaraensis shows ATP-independent activity on unfolded substrates and ATP-dependent activity on folded proteins Thermococcus kodakarensis ?
-
 ?
additional information recombinant LonB protease shows ATPase and protease activities Thermoplasma acidophilum ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii ATCC 43099 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii NCIMB 2012 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii NBRC 102185 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Archaeoglobus fulgidus NBRC 100126 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii DSM 3394 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Archaeoglobus fulgidus ATCC 49558 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii JCM 8879 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii NCIMB 2190 ?
-
 ?
additional information recombinant LonB protease shows ATPase and protease activities Thermoplasma acidophilum JCM 9062 ?
-
 ?
additional information recombinant LonB protease shows ATPase and protease activities Thermoplasma acidophilum AMRC-C165 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii JCM 8861 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii CIP 104546 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Archaeoglobus fulgidus VC-16 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii DS2 ?
-
 ?
additional information LonB protease showed ATPase and protease activities. The enzyme has DNA-binding capacity in vitro Natrialba magadii MS3 ?
-
 ?
additional information recombinant LonB protease shows ATPase and protease activities Thermoplasma acidophilum ATCC 25905 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii DSM 3757 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Archaeoglobus fulgidus JCM 9628 ?
-
 ?
additional information recombinant LonB protease shows ATPase and protease activities Thermoplasma acidophilum NBRC 15155 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii ATCC 29605 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii NBRC 14742 ?
-
 ?
additional information LonB protease shows ATPase and protease activities Haloferax volcanii VKM B-1768 ?
-
 ?

Synonyms

Synonyms Comment Organism
AF0364
-
 Archaeoglobus fulgidus
ATP-dependent lon protease
-
 Thermococcus kodakarensis
ATP-dependent lon protease
-
 Archaeoglobus fulgidus
ATP-dependent lon protease
-
 Thermoplasma acidophilum
ATP-dependent lon protease
-
 Natrialba magadii
ATP-dependent lon protease
-
 Thermococcus onnurineus
ATP-dependent lon protease
-
 Haloferax volcanii
Nmag_2822
-
 Natrialba magadii
NmLon
-
 Natrialba magadii
Ta1081
-
 Thermoplasma acidophilum
TK1264
-
 Thermococcus kodakarensis
TON_0529
-
 Thermococcus onnurineus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Thermococcus kodakarensis
ATP dependent on Archaeoglobus fulgidus
ATP dependent on Thermoplasma acidophilum
ATP dependent on Natrialba magadii
ATP dependent on Thermococcus onnurineus
ATP dependent on Haloferax volcanii

General Information

General Information Comment Organism
malfunction suboptimal LonB expression affects the content of membrane carotenoids and other lipids. Haloferax volcanii mutant cells deficient in Lon content are more sensitive to puromycin compared to wild-type cells. Deregulation of the cellular concentration of bacterioruberins and other lipids affects membrane stability contributing to the lethal phenotype of the lon knockout mutant Haloferax volcanii
additional information the enzyme has a Ser-Lys catalytic dyad Thermoplasma acidophilum
physiological function membrane-bound ATP-dependent Lon protease is essential for cell viability and quality control of proteins, it affects membrane carotenoid content in Haloferax volanii. Enzyme LonB controls carotenoid biosynthesis in Haloferax volcanii probably by degrading enzyme/s involved in this pathway. LonB is implicated in bacterioruberin biosynthesis and protein quality control Haloferax volcanii
physiological function the enzyme can complement a LonB mutant in Haloferax volcanii suggesting functional conservation of LonB Natrialba magadii