Application | Comment | Organism |
---|---|---|
diagnostics | high levels of LONP1 are a poor prognosis marker in human colorectal cancer and melanoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene Lonp1 | Homo sapiens |
gene Lonp1 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | homozygous deletion of gene Lonp1 | Homo sapiens |
additional information | homozygous deletion of gene Lonp1 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene Lonp1 | - |
Mus musculus | Q8CGK3 | gene Lonp1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon cancer cell | - |
Mus musculus | - |
colonic cancer cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
melanoma cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent lon protease | - |
Homo sapiens |
ATP-dependent lon protease | - |
Mus musculus |
lon protease | - |
Homo sapiens |
lon protease | - |
Mus musculus |
LONP1 | - |
Homo sapiens |
LONP1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | homozygous deletion of Lonp1 causes early embryonic lethality, whereas its haploinsufficiency protects against colorectal and skin tumors. LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, phenotypes, overview. LONP1 is necessary for proliferation and metastasis of melanoma cells | Mus musculus |
malfunction | overexpression of the enzyme increases tumorigenesis, high levels of LONP1 are a poor prognosis marker in human colorectal cancer and melanoma, phenotypes, overview | Homo sapiens |
physiological function | the enzyme plays a key role in metabolic reprogramming by remodeling OXPHOS complexes and protecting against senescence. The protease is a central regulator of mitochondrial activity in oncogenesis. LONP1 is necessary for proliferation and metastasis of melanoma cells | Homo sapiens |
physiological function | the enzyme plays a key role in metabolic reprogramming by remodeling OXPHOS complexes and protecting against senescence. The protease is a central regulator of mitochondrial activity in oncogenesis. Role of LONP1 in the regulation of mitochondrial function in cancer, overview | Mus musculus |