Literature summary for 3.4.21.53 extracted from

Kim, S.W.; Moon, K.H.; Baik, H.S.; Kang, H.Y.; Kim, S.K.; Bahk, J.D.; Hur, J.; Lee, J.H.
Changes of physiological and biochemical properties of Salmonella enterica serovar Typhimurium by deletion of cpxR and lon genes using allelic exchange method (2009), J. Microbiol. Methods, 79, 314-320.

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Application

Application	Comment	Organism
medicine	lon single and cpxR and lon double mutants produce 2.0- and 3.2fold increases, respectively, of capsular polysaccharide, which is a major antigenic component. Approximately 104fold attenuation assessed by analysis of LD50 of BALB/c mouse is observed by deleting the lon/cpxR genes	Salmonella enterica

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica	-	serovar typhimurium	-

General Information

General Information	Comment	Organism
physiological function	deletion of genes cpxR and lon results in mutants highly similar to wild-type. In comparison with the wild-type, 1.5- to 3.3fold increases of fimbrial products such as Agf, Fim, and Pef fimbria are observed in the single and double mutants. lon single and cpxR and lon double mutants morphologically appear elongated in shape and produce 2.0- and 3.2fold increases, respectively, of capsular polysaccharide, which is a major antigenic component. Approximately 104fold attenuation assessed by analysis of LD50 of BALB/c mouse is observed by deleting the lon/cpxR genes	Salmonella enterica

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Release 2023.1 (January 2023)