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Literature summary for 3.4.21.53 extracted from

  • Bayot, A.; Gareil, M.; Rogowska-Wrzesinska, A.; Roepstorff, P.; Friguet, B.; Bulteau, A.L.
    Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1 (2010), J. Biol. Chem., 285, 11445-11457.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial ATP-dependent proteolytic activity is reduced by 35% in Deltapim1 cells. Oxidized proteins accumulate at elevated levels in mitochondria lacking pim1 activity Saccharomyces cerevisiae 5739
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ald4 + H2O i.e. potassium-activated aldehyde dehydrogenase, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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 ?
Atp2 + H2O i.e. F1F0-ATP synthase subunit beta, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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HSP60 + H2O i.e. heat shock protein 60, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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Ilv5 + H2O i.e. ketol acid reductoisomerase, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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Lpd1 + H2O i.e. dihydrolipoamide dehydrogenase E3 component of pyruvate dehydrogenase complex, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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Mrp20 + H2O i.e. mitochondrial subunit of the large ribosomal particle, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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Pdb1 + H2O i.e. pyruvate dehydrogenase E1component subunit beta, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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Sod2 + H2O i.e. mitochondrial superoxide dismutase, displays an oxidation index greater than 1 and accumulates in mitochondria lacking pim1 activity Saccharomyces cerevisiae ?
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General Information

General Information Comment Organism
physiological function Pim1-mediated proteolysis is required for elimination of oxidatively damaged proteins in mitochondria. Pim1 plays a prevalent role in mitochondrial protein quality control Saccharomyces cerevisiae