Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.53 extracted from

  • Ngo, J.K.; Davies, K.J.
    Mitochondrial Lon protease is a human stress protein (2009), Free Radic. Biol. Med., 46, 1042-1048.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
rhabdomyosarcoma cell
-
Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens modest induction of mRNA after H2O2 treatment, with the highest inductions of 2.3fold at 4 h and 1.7fold at 7 h observed when the cells are treated with 0.100 mM H2O2 and 1.9fold at 4 h and 1.6fold at 7 h after 0.200 mM H2O2 treatment. Cells exposed to a 45°C heat shock exhibit an 80% induction of Lon protein after 1 h of shock, and 31% induction after 3 h recovery, gradually returning to basal levels at 6 and 24 h. Lon up-regulation by heat-shock is accompanied by a coinduction of mtHSP-70, which exhibits a 70% increase after 1 h of heat shock and declines to basal levels thereafter. Serum starvation stress for 1 h does not increase Lon levels. After recovery for 3 h in serum-supplemented medium, Lon protein levels exhibit a 4-fold increase. Lon protein levels after 6 and 24 h of serum starvation stress recovery remains relatively high, with protein inductions of about 3.8- and 3.1fold, respectively up

General Information

General Information Comment Organism
physiological function the Lon protease is a stress-responsive protein that is induced by multiple stressors, including heat shock, serum starvation, and oxidative stress. Lon induction, by pretreatment with low-level stress, protects against oxidative protein damage, diminished mitochondrial function, and loss of cell proliferation induced by toxic levels of hydrogen peroxide. Blocking Lon induction with Lon siRNA also blocks this induced protection Homo sapiens