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Literature summary for 3.4.21.53 extracted from
- Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin (2007), Antimicrob. Agents Chemother., 51, 4276-4283.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | expression of lon increases over time when bacteria are grown in subinhibitory ciprofloxacin concentrations. Subinhibitory antibiotic environments contribute to the development of resistance | Pseudomonas aeruginosa |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential therapeutic antimicrobial target to combat fluoroquinolone resistance | Pseudomonas aeruginosa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutants in PA1803, a close homolog of the ATP-dependent lon protease, exhibit more than 4fold-increased susceptibilities to ciprofloxacin and 2fold more susceptibilities to norfloxacin and nalidixic acid, but not to gentamicin or imipenem, as well as a characteristic elongated morphology. Complementation of the lon mutant restores wild-type antibiotic susceptibility and cell morphology | Pseudomonas aeruginosa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
PAO1 strain H103 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon | - |
Pseudomonas aeruginosa |
| lon protease | - |
Pseudomonas aeruginosa |
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