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Literature summary for 3.4.21.53 extracted from

  • Wang, N.; Gottesman, S.; Willingham, M.C.; Gottesman, M.M.; Maurizi, M.R.
    A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease (1993), Proc. Natl. Acad. Sci. USA, 90, 11247-11251.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
cDNA clone pHHCPK77, 51 kDa fragment expressed in Escherichia coli BL21(DE3) Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid sequence compared to other Lon-protein sequences Brevibacillus brevis
additional information
-
amino acid sequence compared to other Lon-protein sequences Escherichia coli
additional information
-
amino acid sequence compared to other Lon-protein sequences Homo sapiens
additional information
-
amino acid sequence compared to other Lon-protein sequences Myxococcus xanthus
100000
-
Western blotting Homo sapiens
106000
-
calculated from cDNA Homo sapiens

Organism

Organism UniProt Comment Textmining
Brevibacillus brevis
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Homo sapiens P36776 human
-
Myxococcus xanthus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain hippocampus, human Homo sapiens
-
additional information expression in human tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O alpha-casein Brevibacillus brevis hydrolyzed casein
-
?
casein + H2O alpha-casein Escherichia coli hydrolyzed casein
-
?
casein + H2O alpha-casein Homo sapiens hydrolyzed casein
-
?
casein + H2O alpha-casein Myxococcus xanthus hydrolyzed casein
-
?
Succinyl-Phe-Ala-Phe-methoxynaphthylamide + H2O
-
Escherichia coli Succinyl-Phe-Ala-Phe + methoxynaphthylamine
-
?
Succinyl-Phe-Ala-Phe-methoxynaphthylamide + H2O
-
Homo sapiens Succinyl-Phe-Ala-Phe + methoxynaphthylamine
-
?

Synonyms

Synonyms Comment Organism
human ATP-dependent protease
-
Homo sapiens
human lon protease
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Brevibacillus brevis
37
-
assay at Escherichia coli
37
-
assay at Homo sapiens
37
-
assay at Myxococcus xanthus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP ATP-dependent protease Brevibacillus brevis
ATP ATP-dependent protease Escherichia coli
ATP ATP-dependent protease Myxococcus xanthus
ATP ATP-dependent protease Homo sapiens