Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTP | not | Rattus norvegicus | |
additional information | no activation by ubiquitin | Rattus norvegicus | |
additional information | ATP cannot be replaced by nucleoside diphosphates, nucleoside monophosphates, 5'-adenylyl-betagamma-methylene diphosphate, NADP+, NAD+ | Rattus norvegicus |
General Stability | Organism |
---|---|
2-mercaptoethanol stabilizes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azide | weak | Rattus norvegicus | |
chymostatin | not (casein as substrate) | Rattus norvegicus | |
diisopropyl fluorophosphate | 10 mM, casein as substrate | Rattus norvegicus | |
EDTA | casein as substrate; strong | Rattus norvegicus | |
iodoacetamide | 10 mM, casein as substrate | Rattus norvegicus | |
Mersalyl acid | strong, 5 mM, casein as substrate | Rattus norvegicus | |
additional information | no inhibition by ubiquitin, bestatin, soybean trypsin inhibitor, aprotinin, leupeptin | Rattus norvegicus | |
N,N'-dicyclohexylcarbodiimide | weak | Rattus norvegicus | |
N-ethylmaleimide | not (casein as substrate) | Rattus norvegicus | |
oligomycin | weak | Rattus norvegicus | |
PMSF | 1 mM, casein as substrate | Rattus norvegicus | |
quercetin | 0.1 mM | Rattus norvegicus | |
tosyl-Lys chloromethyl ketone | not (casein as substrate) | Rattus norvegicus | |
tosyl-Phe chloromethyl ketone | not (casein as substrate) | Rattus norvegicus | |
Triton X-100 | 0.05% | Rattus norvegicus | |
vanadate | 0.1 mM; casein as substrate | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
diphosphate | not | Rattus norvegicus | |
Mg2+ | requirement | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
550000 | - |
rat, gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | ATP-dependent serine protease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | methylcasein | Rattus norvegicus | hydrolyzed casein | - |
? | |
Methylglobin + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | ATP-dependent serine protease | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.8 | 10 | about half-maximal activity at pH 6.8 and maximal activity at pH 10, very little activity below 6 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | at physiological concentrations | Rattus norvegicus | |
ATP | activation only in the presence of Mg2+ | Rattus norvegicus | |
ATP | ATP-dependent protease | Rattus norvegicus | |
ATP | ATP hydrolysis is essential for hydrolysis of proteins | Rattus norvegicus | |
CTP | activation | Rattus norvegicus | |
CTP | less efficient than ATP | Rattus norvegicus | |
UTP | activation | Rattus norvegicus | |
UTP | less efficient than ATP | Rattus norvegicus |