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Literature summary for 3.4.21.53 extracted from

  • Desautels, M.; Goldberg, A.L.
    Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria (1982), J. Biol. Chem., 257, 11673-11679.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
GTP not Rattus norvegicus
additional information no activation by ubiquitin Rattus norvegicus
additional information ATP cannot be replaced by nucleoside diphosphates, nucleoside monophosphates, 5'-adenylyl-betagamma-methylene diphosphate, NADP+, NAD+ Rattus norvegicus

General Stability

General Stability Organism
2-mercaptoethanol stabilizes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
azide weak Rattus norvegicus
chymostatin not (casein as substrate) Rattus norvegicus
diisopropyl fluorophosphate 10 mM, casein as substrate Rattus norvegicus
EDTA casein as substrate; strong Rattus norvegicus
iodoacetamide 10 mM, casein as substrate Rattus norvegicus
Mersalyl acid strong, 5 mM, casein as substrate Rattus norvegicus
additional information no inhibition by ubiquitin, bestatin, soybean trypsin inhibitor, aprotinin, leupeptin Rattus norvegicus
N,N'-dicyclohexylcarbodiimide weak Rattus norvegicus
N-ethylmaleimide not (casein as substrate) Rattus norvegicus
oligomycin weak Rattus norvegicus
PMSF 1 mM, casein as substrate Rattus norvegicus
quercetin 0.1 mM Rattus norvegicus
tosyl-Lys chloromethyl ketone not (casein as substrate) Rattus norvegicus
tosyl-Phe chloromethyl ketone not (casein as substrate) Rattus norvegicus
Triton X-100 0.05% Rattus norvegicus
vanadate 0.1 mM; casein as substrate Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
diphosphate not Rattus norvegicus
Mg2+ requirement Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
550000
-
rat, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ATP-dependent serine protease ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O methylcasein Rattus norvegicus hydrolyzed casein
-
?
Methylglobin + H2O
-
Rattus norvegicus ?
-
?
additional information ATP-dependent serine protease Rattus norvegicus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.8 10 about half-maximal activity at pH 6.8 and maximal activity at pH 10, very little activity below 6 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP at physiological concentrations Rattus norvegicus
ATP activation only in the presence of Mg2+ Rattus norvegicus
ATP ATP-dependent protease Rattus norvegicus
ATP ATP hydrolysis is essential for hydrolysis of proteins Rattus norvegicus
CTP activation Rattus norvegicus
CTP less efficient than ATP Rattus norvegicus
UTP activation Rattus norvegicus
UTP less efficient than ATP Rattus norvegicus