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Literature summary for 3.4.21.50 extracted from
- pH dependency of the carboxyl oxygen exchange reaction catalyzed by lysyl endopeptidase and trypsin (2006), J. Proteome Res., 5, 1667-1673.
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | Lys C is used to incorporate two 18O atoms into the carboxyl termini of peptides for proteomics | Achromobacter lyticus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.59 | - |
N-acetyl-L-lysine | pH 9, rate of carboxyl oxygen exchange reaction by Lys-C is accelerated at acidic pH conditions. | Achromobacter lyticus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Achromobacter lyticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-lysine + H2O | - |
Achromobacter lyticus | N-acetyl-L-lysine + H2O | incorporation of O18 atom into the carboxyl group | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Lys-C | - |
Achromobacter lyticus |
| Lysyl endopeptidase | - |
Achromobacter lyticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
for carboxyl oxygen exchange activity | Achromobacter lyticus |
| 8 | - |
for amidase activity | Achromobacter lyticus |
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