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Literature summary for 3.4.21.5 extracted from

  • Choi, S.H.; Smith, S.A.; Morrissey, J.H.
    Polyphosphate is a cofactor for the activation of factor XI by thrombin (2011), Blood, 118, 6963-6970.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.5

Activating Compound

Activating Compound Comment Organism Structure
Polyphosphate PolyP, secreted by activated platelets, a highly anionic polymer, polyphosphate plus beta-thrombin accelerates plasma clotting and enhances thrombin generation, kinetics, overview. Thrombin binds with high affinity to immobilized polyphosphate. Polyphosphate accelerates factor XI autoactivation and factor XIa autolysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XI + H2O Homo sapiens activation by thrombin factor XIa + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification thrombinogen activation to thrombin by factor Va Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XI + H2O activation by thrombin Homo sapiens factor XIa + ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
 Homo sapiens
beta-thrombin
-
 Homo sapiens