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Literature summary for 3.4.21.5 extracted from

  • Kawanami, D.; Matoba, K.; Kanazawa, Y.; Ishizawa, S.; Yokota, T.; Utsunomiya, K.
    Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-kappaB signaling pathway activation in vascular endothelial cells (2011), Biochem. Biophys. Res. Commun., 411, 798-803.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Y-27632 attenuates thrombin-mediated phosphorylation of p38MAPK and p65 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification active thrombin is generated from thrombinogen by proteolytic cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-
vascular endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

General Information

General Information Comment Organism
physiological function Thrombin is a multifunctional serine protease generated by the cleavage of prothrombin at sites of vascular injury, and promotes the conversion of fibrinogen to fibrin. thrombin induces monocyte chemoattractant protein 1, MCP-1, expression through Rho-kinase and subsequent p38MAPK/NF-kappaB signaling pathway activation in vascular endothelial cells leading to the development of atherosclerosis, the Rho/Rho-kinase signaling pathway plays a critical role in thrombin-mediated MCP-1 expression and function, Rho-kinase mediates thrombin-induced MCP-1 expression through p38MAPK and NF-jB activation, mechanism, overview Homo sapiens