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Literature summary for 3.4.21.5 extracted from
- The influence of direct thrombin inhibitors on the formation of platelet-leukocyte aggregates and tissue factor expression (2010), Thromb. Res., 126, e327-e333.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dabigatran | thrombin is inhibited by 300 ng/ml | Homo sapiens |  |
| melagatran | direct thrombin inhibitor, inhibited by 0.001 mM | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-thrombin | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in vitro, thrombin and ADP increase the formation of platelet-monocyte aggregates and platelet-granulocyte aggregates as well as tissue factor mRNA expression | Homo sapiens |
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Release 2023.1 (January 2023)
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