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Literature summary for 3.4.21.5 extracted from

  • Papareddy, P.; Rydengard, V.; Pasupuleti, M.; Walse, B.; Moergelin, M.; Chalupka, A.; Malmsten, M.; Schmidtchen, A.
    Proteolysis of human thrombin generates novel host defense peptides (2010), PLoS Pathog., 6, e1000857.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

General Information

General Information Comment Organism
physiological function thrombin is a key enzyme in the coagulation cascade. Proteolysis of prothrombin and thrombin generates antimicrobial activity Homo sapiens