Crystallization (Comment) | Organism |
---|---|
thrombin in complex with hirudin, hanging drop vapor diffusion method, using 0.05 M sodium phosphate buffer pH 7.3, 28% (w/v) PEG8000 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-1-(1,3-benzodioxol-5-ylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-(cyclohexylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-methylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-propylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-methylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-propylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]-N-methylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[(2R)-2-cyclohexyl-2-hydroxyacetyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
(2S)-1-[3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide | - |
Homo sapiens | |
1-(2-amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid isobutyl-amide | - |
Homo sapiens | |
1-(2-cyclohexyl-2-phenylmethanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid methylamide | - |
Homo sapiens | |
1-(3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid methylamide | - |
Homo sapiens | |
1-(3,3-diphenylpropanoyl)-N-(thiophen-2-ylmethyl)-L-prolinamide | - |
Homo sapiens | |
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(cyclohexylmethyl)-L-prolinamide | - |
Homo sapiens | |
1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide | - |
Homo sapiens | |
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-propyl-L-prolinamide | - |
Homo sapiens | |
1-[(9-hydroxy-9H-fluoren-9-yl)acetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide | - |
Homo sapiens | |
1-[2-amino-3-(4-chloro-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid methylamide | - |
Homo sapiens | |
1-[3-(4-chloro-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid methylamide | - |
Homo sapiens | |
3-(1,3-benzodioxol-5-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-methyl-L-prolinamide | - |
Homo sapiens | |
3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-propyl-L-prolinamide | - |
Homo sapiens | |
3-cyclohexyl-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
3-cyclohexyl-D-alanyl-N-propyl-L-prolinamide | - |
Homo sapiens | |
4-chloro-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
beta-phenyl-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide | - |
Homo sapiens | |
beta-phenyl-D-phenylalanyl-N-(thiophen-2-ylmethyl)-L-prolinamide | - |
Homo sapiens | |
beta-phenyl-D-phenylalanyl-N-methyl-L-prolinamide | - |
Homo sapiens | |
beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide | - |
Homo sapiens | |
Hirudin | - |
Homo sapiens | |
melagatran | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-thrombin | - |
Homo sapiens |
factor IIa | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0016 | - |
at 37°C | Homo sapiens | beta-phenyl-D-phenylalanyl-N-(thiophen-2-ylmethyl)-L-prolinamide | |
0.0042 | - |
at 37°C | Homo sapiens | 1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide | |
0.013 | - |
at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | |
0.018 | - |
at 37°C | Homo sapiens | beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide | |
0.02 | - |
at 37°C | Homo sapiens | 1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(cyclohexylmethyl)-L-prolinamide | |
0.049 | - |
at 37°C | Homo sapiens | 1-[(9-hydroxy-9H-fluoren-9-yl)acetyl]-N-(thiophen-2-ylmethyl)-L-prolinamide | |
0.089 | - |
at 37°C | Homo sapiens | beta-phenyl-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide | |
0.12 | - |
at 37°C | Homo sapiens | 1-(3,3-diphenylpropanoyl)-N-(thiophen-2-ylmethyl)-L-prolinamide | |
0.12 | - |
at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-propylpyrrolidine-2-carboxamide | |
0.17 | - |
at 37°C | Homo sapiens | 1-(2-cyclohexyl-2-phenylmethanesulfonylamino-acetyl)-pyrrolidine-2-carboxylic acid methylamide | |
0.21 | - |
at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide | |
0.23 | - |
at 37°C | Homo sapiens | beta-phenyl-D-phenylalanyl-N-methyl-L-prolinamide | |
0.23 | - |
at 37°C | Homo sapiens | 1-(2-amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid isobutyl-amide | |
0.38 | - |
at 37°C | Homo sapiens | 3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-propyl-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 3-(1,3-benzodioxol-5-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-methylpyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[3-(4-chlorophenyl)propanoyl]-N-propylpyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-methyl-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 3-cyclohexyl-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 1-[(2R)-2-amino-2-cyclohexylacetyl]-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 1-[(2R)-2-amino-4,4-diphenylbutanoyl]-N-propyl-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-(1,3-benzodioxol-5-ylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-propylpyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-(cyclohexylacetyl)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[(2R)-2-cyclohexyl-2-hydroxyacetyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]-N-methylpyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(2-methoxyethyl)pyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[3-(4-chlorophenyl)propanoyl]-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 3-cyclohexyl-D-alanyl-N-propyl-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 3-(9-hydroxy-9H-fluoren-9-yl)-D-alanyl-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | 4-chloro-D-phenylalanyl-N-(2-methoxyethyl)-L-prolinamide | |
0.4 | - |
IC50 above 0.4 mM, at 37°C | Homo sapiens | (2S)-1-[(2R)-2-amino-3-(1,3-benzodioxol-5-yl)propanoyl]-N-methylpyrrolidine-2-carboxamide |