Literature summary for 3.4.21.5 extracted from

Zhang, T.; Ma, Z.; Wang, R.; Wang, Y.; Wang, S.; Cheng, Z.; Xu, H.; Jin, X.; Li, W.; Wang, X.
Thrombin facilitates invasion of ovarian cancer along peritoneum by inducing monocyte differentiation toward tumor-associated macrophage-like cells (2010), Cancer Immunol. Immunother., 59, 1097-1108.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Hirudin	specific inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fibrinogen + H2O	Homo sapiens	-	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fibrinogen + H2O	-	Homo sapiens	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

General Information

General Information	Comment	Organism
physiological function	thrombin facilitates invasion of ovarian cancer along peritoneum by inducing monocyte differentiation toward tumor-associated macrophage-like cells. Thrombin induces monocytes differentiation into M2-like macrophages with tumor-associated macrophage characteristics. Thrombin does not influence monocytes phagocytosis function significantly	Homo sapiens

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Release 2023.1 (January 2023)