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Literature summary for 3.4.21.5 extracted from

  • Pu, J.; Yang, T.
    Thrombin: A potential regulator between head injury and enhanced osteogenesis (2009), Biosci. Hypotheses, 2, 326-328.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens thrombin is generated by proteolysis of its precursor prothrombin at sites of injury ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
additional information craniocerebral trauma patients present a state of hypercoagulability at early stage and thrombin content is very high level at the site of injury Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information thrombin is generated by proteolysis of its precursor prothrombin at sites of injury Homo sapiens ?
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?

General Information

General Information Comment Organism
physiological function thrombin is involved in blood coagulation and wound healing, thrombin may be a potential regulator of early fracture healing, which results in accelerated bone healing and hypertrophic callus. Activation of PAR-1 by thrombin may be one key regulator of COX-2 expression immediately following injury. Thrombin exerts multiple effects upon osteoblasts including stimulating proliferation, and inhibiting osteoblast differentiation and apoptosis. The pro-inflammatory effects of thrombin are mediated through activation of endothelial cells, smooth muscle cells, and platelets as well as release of cellular mediators. Thrombin also induces brain inflammation by activating microglia Homo sapiens