Literature summary for 3.4.21.5 extracted from

Lima, L.M.; Becker, C.F.; Giesel, G.M.; Marques, A.F.; Cargnelutti, M.T.; de Oliveira Neto, M.; Monteiro, R.Q.; Verli, H.; Polikarpov, I.
Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases (2009), Biochim. Biophys. Acta, 1794, 873-881.

Search for more literature for 3.4.21.5

Crystallization (Commentary)

Crystallization (Comment)	Organism
thrombin-suramin complex refined at 2.4 A resolution,. hanging drop vapor diffusion method, using 400 mM NaCl, 20 mM MES pH 6.0, 25% (v/v) tert-butanol, 100 mM Tris pH 8.5	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
D-Phe-L-Pro-L-Arg-chloromethylketone	-	Homo sapiens
suramin	i.e. 8, 8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, non-competitive inhibitor of human alpha-thrombin activity over fibrinogen	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
fibrinogen + H2O	Homo sapiens	-	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00734	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O	-	Homo sapiens	D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline	-	?
fibrinogen + H2O	-	Homo sapiens	fibrin + fibrinopeptide A + fibrinopeptide B	-	?

Synonyms

Synonyms	Comment	Organism
alpha-thrombin	-	Homo sapiens
alphaTh	-	Homo sapiens

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Release 2023.1 (January 2023)