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Literature summary for 3.4.21.5 extracted from

  • Kovach, I.M.; Kelley, P.; Eddy, C.; Jordan, F.; Baykal, A.
    Proton bridging in the interactions of thrombin with small inhibitors (2009), Biochemistry, 48, 7296-7304.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-nitrophenyl 2-propyl methylphosphonate
-
Homo sapiens
L-Phe-L-Pro-L-Arg-chloromethylketone
-
Homo sapiens
paraoxon
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36500
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
-
Homo sapiens D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
?
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000024
-
L-Phe-L-Pro-L-Arg-chloromethylketone at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C Homo sapiens
0.1
-
paraoxon IC50 above 0.1 mM, at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C Homo sapiens
0.1
-
4-nitrophenyl 2-propyl methylphosphonate IC50 above 0.1 mM, at pH 7.0 in 0.05 M phosphate buffer and 0.15 M NaCl at 25°C Homo sapiens