Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel wall | sections from Alzheimer's disease brains show reactivity to thrombin antibody in blood vessel walls but not in vessels from controls | Homo sapiens | - |
brain endothelium | - |
Rattus norvegicus | - |
brain endothelium | brain endothelial cells can synthesize thrombin and thus be a source of this neurotoxin in Alzheimer's disease brains | Homo sapiens | - |
cerebrospinal fluid | high levels of thrombin are detected in cerebrospinal fluid obtained from Alzheimer's disease but not control patients | Homo sapiens | - |
microvessel | thrombin is highly expressed in microvessels from Alzheimer's disease brains but is not detectable in control vessels | Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells | up |
Rattus norvegicus | oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells | up |