Literature summary for 3.4.21.5 extracted from

Feutz, A.C.; Barrandon, Y.; Monard, D.
Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells (2008), J. Cell Sci., 121, 1435-1443.

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Protein Variants

Protein Variants	Comment	Organism
additional information	in mice homozygously lacking the thrombin inhibitor protease nexin, the PI3K-Akt pathway is constitutively activated and expression of myofibroblastic marker smooth-muscle actin is enhanced in vivo in hair follicle dermal cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dermal papilla	thrombin induces a phosphoinositide 3-kinase-Akt pathway-dependent acquisition of dermal-sheath-like properties by dermal papilla cells in vitro, involving increased proliferation rate, acquisition of myofibroblastic contractile properties and a decreased capacity to sustain growth and survival of keratinocytes. The thrombin inhibitor protease nexin 1 regulates all those effects in vitro. Control of thrombin signaling interferes with hair follicle dermal cells plasticity to regulate their function	Mus musculus	-
hair follicle	-	Mus musculus	-

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Release 2023.1 (January 2023)