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Literature summary for 3.4.21.5 extracted from
- Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury (2009), Ann. Thorac. Surg., 87, 786-793.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | treatment of pigs that underwent mid-left anterior descending coronary artery occlusion followed by reperfusion with saline vehicle or thrombin fragment TP508, i.e. chrysalin as a bolus into the ischemic period followed by continuous intravenous infusion. Endothelium-dependent coronary microvascular relaxation is greater in the TP508 group and associated with higher endothelial nitric oxide synthase phosphorylation. Both infarct size and TUNEL staining is decreased in the TP508 group compared with the saline control group. ession of cell survival proteins B-cell lymphoma and heat shock protein-73 is higher in the TB508 group. Expression of cell death-signaling proteins polyadenosine-diphosphate-ribose polymerase, cleaved polyadenosine-diphosphate-ribose polymerase, and B-cell lymphoma2/adenovirus E1B 19 kDa-interacting protein is significantly higher in the TB508 group in the ischemic territory | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
Yucatan pig | - |
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Release 2023.1 (January 2023)
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